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Mice receiving T4 after coronary artery ligation showed significantly smaller necrosis areas compared to controls [2]

To verify the accuracy of BBB-PAMPA and MDR1-MDCK I models in predicting brain penetration, 24 commercial compounds, including 10 BBB permeable (CNS+) compounds and 14 BBB impermeable compounds (CNS-) [3-7] , were evaluated

242-246 In one placebo-controlled trial that included 60 participants with anxiety and depression, 50 mg saffron daily for 12 weeks reduced scores on tests assessing anxiety and depression symptoms